Durogesic D-Trans Description

Durogesic is a transdermal system providing continuous systemic delivery of fentanyl, a potent opioid analgesic, for 72 hours. Durogesic is a rectangular transparent patch comprising a protective layer and two functional layers. From the outer surface to the surface adhering to the skin, these layers are: a backing layer of polyester; an adhesive layer of polyacrylate with fentanyl.
Durogesic is available in different strengths, the composition of which per unit area is identical. The strength is imprinted on the patch in orange, pink, and green on Durogesic 12, 25, and 50 μg/hour patches respectively.
Apart from fentanyl, there are no other active components.
Durogesic 12 μg/hour: Active substance: fentanyl 2.1 mg.
The surface area is 5.25 cm². The system releases approximately 12.5 μg/hour fentanyl into the systemic circulation (which represents 0.3 mg/24h).
Durogesic 25 μg/hour: Active substance: fentanyl 4.2 mg.
The surface area is 10.5 cm². The system releases approximately 25 μg/hour fentanyl into the systemic circulation (which represents 0.6 mg/24h).
Durogesic 50 μg/hour: Active substance: fentanyl 8.4 mg.
The surface area is 21.0 cm². The system releases approximately 50 μg/hour fentanyl into the systemic circulation (which represents 1.2 mg/24h).
Excipients/Inactive Ingredients: Durogesic 12 μg/hour: Backing: polyethylene terephthalate (PET) / ethylene-vinyl acetate (EVA) copolymer.
Adhesive layer: polyacrylate Duro-Tak 87-4287.
Protective liner: siliconized polyethylene terephthalate.
Orange ink.
Durogesic 25 μg/hour: Backing: polyethylene terephthalate (PET) / ethylene-vinyl acetate (EVA) copolymer.
Adhesive layer: polyacrylate Duro-Tak 87-4287.
Protective liner: siliconized polyethylene terephthalate.
Red ink.
Durogesic 50 μg/hour: Backing: polyethylene terephthalate (PET) / ethylene-vinyl acetate (EVA) copolymer.
Adhesive layer: polyacrylate Duro-Tak 87-4287.
Protective liner: siliconized polyethylene terephthalate.
Green ink.